The invention in 1986 of scanning force microscopy (SFM) provided a new and powerful tool for the investigation of biological structures. SFM yields a three‐dimensional view at nanometer resolution of the surface topography associated with biological objects. The potential for imaging either macromolecules or biomolecules and cells under native (physiological) conditions is currently being exploited to obtain functional information at the molecular level. In addition, the forces involved in individual bimolecular interactions are being assessed under static and dynamic conditions. In (...) this report we focus on the imaging capability of the SFM. The rather broad spectrum of applications represented is intended to orient the prospective user of biological SFM. (shrink)

Thomas Aquinas produced a voluminous body of work on moral theory, and much of that work is on virtue, particularly the status and value of the virtues as principles of virtuous acts, and the way in which a moral life can be organized around them schematically. Thomas Osborne presents Aquinas's account of virtue in its historical, philosophical and theological contexts, to show the reader what Aquinas himself wished to teach about virtue. His discussion makes the complexities of Aquinas's (...) moral thought accessible to readers despite the differences between Thomas's texts themselves, and the distance between our background assumptions and his. The book will be valuable for scholars and students in ethics, medieval philosophy, and theology. (shrink)

Abstract:To date, our understanding of ethical decision making and behavior in organizations has been concentrated in the area of moral judgment, largely because of the hundreds of studies done involving cognitive moral development. This paper addresses the problem of our relative lack of understanding in other areas of human morality by applying a recently developed construct—moral approbation—to illuminate the link between moral judgment and moral action. This recent work is extended here by exploring the effect that organizations have on ethical (...) behavior in terms of the moral approbation construct. (shrink)

" Our various cultures are symbolic environments or "spiritual ecologies" within which the Human Eros can thrive. This is how we inhabit the earth. Encircling and sustaining our cultural existence is nature.

Internalism about epistemic justification (henceforth, ‘internalism’) says that a belief B is epistemically justified for S only if S is aware of some good-making feature of B, some feature that makes for B’s having positive epistemic status: e.g., evidence for B. Externalists with respect to epistemic justification (‘externalists’) deny this awareness requirement. Michael Bergmann has recently put this dilemma against internalism: awareness admits of a strong and a weak construal; given the strong construal, internalism is subject to debilitating regress troubles; (...) given the weak construal, internalism is unmotivated; either way, internalism is in serious trouble. I argue for two claims in this article. First, Bergmann’s dilemma argument is unmotivated: he’s given no good reason for accepting one of its crucial premises. And second, Bergmann’s dilemma argument is unsound: the crucial premise in question is false. (shrink)

ABSTRACT: Indifference is a term often used to describe the sort of freedom had by the will according to the libertarian, or Molinist account. It is thought to be a univocal term. In fact, however, it is used in at least seven different ways, in a variety of domains during the early modern period. All of them have plausible roots in Descartes, but he himself uses the term in only one sense, and failure to notice this consistent use by him (...) has bedeviled interpretations of his account of the will. (shrink)

Beginning with the well-knowncyber-rape in LambdaMOO, I argue that it ispossible to have real moral wrongs in virtualcommunities. I then generalize the account toshow how it applies to interactions in gamingand discussion communities. My account issupported by a view of moral realism thatacknowledges entities like intentions andcausal properties of actions. Austin's speechact theory is used to show that real people canact in virtual communities in ways that bothestablish practices and moral expectations, andwarrant strong identifications betweenthemselves and their online identities. Rawls'conception (...) of a social practice is used toanalyze the nature of the wrong and thestage-setting aspect of engaging in a practice. (shrink)

This clear, accessible text/reference explores the full range of contemporary issues in health care ethics from a practical wisdom approach. The authors present the fundamental concerns of modern medical ethics–-autonomy, beneficence, justice, and confidentiality-–and then provide analysis, cases, and insights from professional literature to discuss them. Throughout, the discussion starts with larger issues or concepts and principles and then focuses on specific problems or complications.

This volume comprises essays presented to Alvin Plantinga on the occasion of his 70th birthday.

According to the “internal” conception (Quong), political liberalism aims to be publicly justifiable only to people who are reasonable in a special sense specified and advocated by political liberalism itself. One advantage of the internal conception allegedly is that it enables liberalism to avoid perfectionism. The paper takes issue with this view. It argues that once the internal conception is duly pitched at its fundamental, metatheoretical level and placed in its proper discursive context, it emerges that it comes at the (...) cost of public dogma. The paper examines this problem and argues that a plausible response to this problem is to go beyond the internal conception and adopt a more inclusive, dynamic conception. But this calls for a form of perfectionism. Thus, the internal conception of political liberalism, far from showing how liberalism can be had without perfectionism, effectively calls for perfectionism as a remedy for its problems. (shrink)

I raise an epistemic objection to naturalistic metaphysics – the attempt to understand the nature and structure of reality in terms of natural entities, forces, and processes – arguing that we should not expect evolution to have crafted cognitive faculties reliable with respect to recondite metaphysical speculation, and that this gives practitioners of naturalistic metaphysics reason to doubt the deliverances of their work. I conclude by considering some main objections to this kind of skeptical argument.

ABSTRACT:Employing utilitarian criteria, Jones and Felps, in “Shareholder Wealth Maximization and Social Welfare: A Utilitarian Critique” (Business Ethics Quarterly23[2]: 207–38), examined the sequential logic leading from shareholder wealth maximization to maximal social welfare and uncovered several serious empirical and conceptual shortcomings. After rendering shareholder wealth maximization seriously compromised as an objective for corporate operations, they provided a set of criteria regarding what a replacement corporate objective would look like, but do not offer a specific alternative. In this article, we draw (...) on neo-utilitarian thought to advance a refined version of normative stakeholder theory that we believe addresses a major remaining criticism of extant versions, their lack of specificity. More particularly, we provide a single-valued objective function for the corporation—stakeholder happiness enhancement—that would allow managers to make principled choices between/among policy options when stakeholder interests conflict. (shrink)

By the mid-1600s, the commonsense, manifest picture of the world associated with Aristotle had been undermined by skeptical arguments on the one hand and by the rise of the New Science on the other. What would be the scientific image to succeed the Aristotelian model? Thomas Lennon argues here that the contest between the supporters of Descartes and the supporters of Gassendi to decide this issue was the most important philosophical debate of the latter half of the seventeenth century. (...) Descartes and Gassendi inspired their followers with radically opposed perspectives on space, the objects in it, and how these objects are known. Lennon maintains that differing concepts on these matters implied significant moral and political differences: the Descartes/Gassendi conflict was typical of Plato's perennial battle of the gods and giants, and the crux of that enduring philosophical struggle is the exercise of moral and political authority. Lennon demonstrates, in addition, that John Locke should be read as having taken up Gassendi's cause against Descartes. In Lennon's reinterpretation of the history of philosophy between the death dates of Gassendi and Malebranche, Locke's acknowledged opposition to Descartes on some issues is applied to the most important questions of Locke exegesis. Originally published in 1993. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905. (shrink)

This article reports the results of a study of attitudes of future business executives towards issues of social responsibility and business ethics. The 455 respondents, who were MBA students during 1985 at one dozen schools from various regions in the United States, were asked to respond to a series of open-ended and closed-ended questions. From the responses to the questions the authors were able to conclude that future executives display considerable sensitivity, though to varying degrees, towards ethical issues in business. (...) Women, in particular, tend to evince strong feelings regarding such issues. (shrink)

Discussion of real cases encountered by medical students has been advocated as a component of medical ethics education. Suggested benefits include: a focus on the actual problems that medical students confront; active learner involvement; and facilitation of an exploration of the meaning of their own values in relation to professional behaviour. However, the approach may also carry risks: students may focus too narrowly on particular clinical topics or show a preference for discussing legal problems that may appear to have clearer (...) solutions. Teaching may therefore omit areas generally considered to be important components of the curriculum. In this paper, the authors present an analysis of the moral problems raised by medical students in response to a request to describe ethically problematic cases they had encountered during two clinical attachments, for the purpose of educational discussion at case-based seminars. We discuss the problems raised and compare the content of the cases to the UK Consensus Statement on core content of learning. The authors also describe the approaches that the students used to undertake an initial analysis of the problems raised, and consider possible implications for the development of medical ethics education. (shrink)

Although previous ethical analyses of management buyouts have presented useful insights, they have been flawed in three major ways. First, they define the transaction too narrowly, emphasizing the going private aspect and ignoring the leveraged aspect. Leveraging alters the nature of the transaction substantially and warrants additional ethical analysis. Second, these previous analyses ignore the impact of buyouts on non-stockholder constituents of the firm, an omission which renders their implicit utilitarian approach incomplete. Third, these analyses do not include Rawlsian, libertarian, (...) or Kantian perspectives on ethics. This paper addresses these shortcomings and finds the ethical status of leveraged management buyouts to be highly suspect. (shrink)

This Element defends a version of the classical theory of divine ideas, the containment exemplarist theory of divine ideas. The classical theory holds that God has ideas of all possible creatures, that these ideas partially explain why God's creation of the world is a rational and free personal action, and that God does not depend on anything external to himself for having the ideas he has. The containment exemplarist version of the classical theory holds that God's own nature is the (...) exemplar of all possible creatures, and therefore that God's ideas of possible creatures are in some sense ideas of himself. Containment exemplarism offers a monotheism fit for metaphysics, insofar as it is coherent, simple, and explanatorily powerful; and offers a metaphysics fit for monotheism, insofar as it leaves God truly worthy of the unconditional worship which Christians, along with Jews and Muslims, aspire to offer to God. (shrink)

This sense of attributability, or internality, is the quarry in many of Frankfurt's articles, and it has proved to be an elusive one. In this paper I want to explore, in a tentative fashion, the question of why we should be interested in finding this quarry. It seems to me that there are at least two quite distinct kinds of reason for this concern, and that when they are distinguished the problem may look less difficult than it has seemed.

Thomas Aquinas, John Duns Scotus, and William of Ockham disagree over how and whether virtues are specified by their objects. For Thomas, habits and acts are specified by their formal objects. For instance, the object of theft is something that belongs to someone else, and more particularly theft is distinct from robbery because theft is the open taking of another’s good, whereas robbery is open and violent. A habit such as a virtue or a vice shares or takes (...) the act’s object. For Scotus, although the same virtue or act cannot have objects which differ formally, different virtues and acts can have an object which is identical according to its formal ratio, in the way that the different theological virtues might even formally have God as their object. Ockham accepts Scotus’s view that charity and hope are two kinds of love, we will see how, unlike Scotus, he argues that these theological virtues differ on account of their immediate complex objects. The disagreement between these three figures raises important difficulties concerning what it even means to be a formal object. (shrink)

Approaches to programming ethical behavior for computer systems face challenges that are both technical and philosophical in nature. In response, an incrementalist account of machine ethics is developed: a successive adaptation of programmed constraints to new, morally relevant abilities in computers. This approach allows progress under conditions of limited knowledge in both ethics and computer systems engineering and suggests reasons that we can circumvent broader philosophical questions about computer intelligence and autonomy.

According to Rainer Forst, (i) moral and political claims must meet a requirement of reciprocal and general acceptability (RGA) while (ii) we are under a duty in engaged discursive practice to justify such claims to others, or be able to do so, on grounds that meet RGA. The paper critically engages this view. I argue that Forst builds a key component of RGA, i.e., reciprocity of reasons, on an idea of the reasonable that undermines both (i) and (ii): if RGA (...) builds on this idea, RGA is viciously regressive and a duty of justification to meet RGA fails to be agent transparent. This negative result opens the door for alternative conceptions of reciprocity and generality. I then suggest that a more promising conception of reciprocity and generality needs to build on an idea of the reasonable that helps to reconcile the emancipatory or protective aspirations of reciprocal and general justification with its egalitarian commitments. But this requires to downgrade RGA in the order of justification and to determine on prior, substantive grounds what level of discursive influence in reciprocal and general justification relevant agents ought to have. (shrink)

In his ethical writings, Duns Scotus emphasized both divine freedom and natural goodness, and these seem to conflict with each other in various ways. I offer an interpretation of Scotus which takes seriously these twin emphases and shows how they cohere. I argue that, for Scotus, all natural laws obtain just by the natures of actual things. Divine commands, such as the Ten Commandments, contingently track natural laws but do not make natural laws to be natural laws. I present textual (...) evidence for this claim. I also show how this view of Scotus on the natural law is consistent with a number of troubling passages. Scotus’s ethical theory implies that there are genuinely moral reasons for acting which are not absolutely binding (because subject to a divine command or permission otherwise) and also some moral reasons for acting which are absolutely binding (because not thus subject). (shrink)

Descartes’s View of the Will Has generally been found problematic and unsatisfactory, especially by those who have read it, or elements of it, in libertarian terms. Attempts to repair the theory, even by sympathetic interpreters, seem only to have aggravated the view’s putative shortcomings—again, especially among those who have read it, or part of it, in libertarian terms—which suggests that the libertarian reading itself might be unsatisfactory. The aim of this paper is to show that the linchpin text on which (...) libertarian readings have been based provides no basis for such readings. The text is the so-called letter to the Jesuit Denis Mesland of 9 February 1645. Among seminal authors—those most .. (shrink)

Purpose Although surrogate decision-making is prevalent in intensive care units and concerns with decision quality are well documented, little is known about how clinicians help family members understand the surrogate role. We investigated whether and how clinicians provide normative guidance to families regarding how to function as a surrogate. Subjects and methods We audiorecorded and transcribed 73 ICU family conferences in which clinicians anticipated discussing goals of care for incapacitated patients at high risk of death. We developed and applied a (...) coding framework to identify normative statements by clinicians regarding what considerations should guide surrogates’ decisions, including whether clinicians explained one or more of Buchanan and Brock’s three standard principles of SDM to family members. Results Clinicians made at least one statement about how to perform the surrogate role in 24 conferences ). We observed three general types of normative guidance provided to surrogates, with some conferences containing more than one type of guidance: counselling about one or more standard principles of SDM ; counselling surrogates to make decisions centred on the patient as a person, without specifying how to accomplish that ; and counselling surrogates to make decisions based on the family’s values. Conclusions Clinicians did not provide normative guidance about the surrogate role in two-thirds of family conferences for incapacitated patients at high risk for death. When they did, clinicians’ guidance was often incomplete and sometimes conflicted with standard principles of SDM. Future work is needed to understand whether providing explicit guidance on how to perform the surrogate role improves decision-making or mitigates surrogates’ psychological distress. (shrink)

growing up in new mexico, I was passionate about geology, specifically paleontology. It led, in one adventure, to me being arrested by monks. While on a picnic with my parents at Jemez Springs, I had followed a beautiful Permian stratum, rich with crinoids and brachiopod shells, onto private land owned by The Servants of the Paraclete, a retreat for "whiskey priests."1 I was detained while one brother admonished me, kindly, and let me go, and even let me keep my specimens. (...) But the passion for the history of the earth and natural history in general remained. I was one of those kids who came late to the idea that what was taught at school and what I found of interest had any points of intersection, but I did come to... (shrink)

This paper is reprinted in the book Machine Ethics, eds. M. Anderson and S. Anderson, Cambridge University Press, 2011.

: A continuation of the debate over the intelligibility, and plausibility, of Yolton's reading of Locke's account of perception. Here, the issue turns on the de‐reification of ideas and its implications for the putative axioms of symmetry and transitivity governing the identity of ideas. The issue is illustrated by what Locke says about confused ideas.

Public justification in political liberalism is often conceptualized in light of Rawls’s view of its role in a hypothetical well-ordered society as an ideal or idealizing form of justification that applies a putatively reasonable conception of political justice to political matters. But Rawls implicates a different idea of public justification in his doctrine of general reflective equilibrium. The paper engages this second, more fundamental idea. Public justification in this second sense is actualist and fundamental. It is actualist in that it (...) fully enfranchises actual reasonable citizens. It is fundamental in that political liberalism qualifies conceptions of political justice as reasonable to begin with only if they can be accepted coherently by actual reasonable citizens. Together, these features invite the long-standing concern that actualist political liberalism is objectionably exclusionary. I argue that the exclusion objection, while plausible, is more problematic in own right than it seems if actualist and fundamental public justification hypotheticalizes and discursive respect is compatible with substantive discursive inequality. This leaves proponents and critics of political liberalism with deeper questions about the nature of permissible discursive inequality in public justification. (shrink)

John Rawls' conception of a reasonable pluralism proceeds on the epistemological assumption that it is not possible to set up one specific notion of justice attached to certain beliefs about the nature ofthe person, the purpose and the goal of human life. The liberal position insists on the principle of moral justification, according to which no norm is legitimate unless it can be accepted in principle by all affected persons. According to this view, it is recommended, in public debates where (...) the legitimacy of laws and state actions is being disputed, citizens should confine themselves to the use of religious arguments for which independent, secular reasons can be given. This conception has elicited an array of critical responses from authors of a religious persuasion. Critics point above all to the unequal terms of entry to public debates. But it can be shown in termsofamodest foundationalist epistemology that the required translation of religious beliefs in secular reasons is not an unfair and unjustified charge. Personally justified basic beliefs can be tested in intersubjective and public procedures of reasoning without requiring believers to sacrifice their religious or confessional identity. (shrink)

The paper aims to put certain basic mathematical elements and operations into an empirical perspective, evaluate the empirical status of various analytic operations widely used within psychology and suggest alternatives to procedures criticized as inadequate. Experimentation shows the "manyness" of items to be a perceptual quality for both young children and animals and that natural operations are performed by naive children analogous to those performed by persons tutored in arithmetic. Number, counting, arithmetic operations therefore can make distinctions that are not (...) inevitably arbitrary, and conceptual operations can obviously have a status as natural events with psychology. If the elements and conceptual operations involved in mathematical systems were not inherent in physiological process, various primitive discriminations could not be possible. Also, since some calculi have a natural status in a given empirical circumstance, the axioms of others can not be satisfied. Therefore the psychologist when acting as an empirical scientist seeks a calculus having a structure whose elements are isomorphic with natural units of stimulus and response and whose operations are isomorphic with whatever natural processes are involved. Measurement poses a special problem for the empirical scientist. It concerns but a single class of natural qualities and this only in a limited way. The concept of quantity has a natural counterpart but quantity and measurement are not wholly analogous. Measurement is defined, as H. S. Leonard suggests, as a theoretical activity. Measurement theory has a formal structure but empirical end. Measurement hypothesizes about the position of a particular quality within a definite range of qualities. It therefore is beholden to definite empirical restrictions. Some hypotheses-making systems use terms and relations per se as the context and starting point for dealing with discriminable events. Such procedures are 'transcendent." In empirical science, questions are part of problem-solving activity and their reference is naturally restricted. In providing description and explanation, psychological researchers frequently use calculi in a transcendent way. This results in theories that are only quasi-empirical and "half" true. The roles measurement plays in psychology are discussed. Of particular concern are those cases in which the results of measuring or a theory of measurement are used to define the "real" units, or the "real" relations involved in problematic psychological events, and thence to describe and explain behaviors of interest. Metaphysical or ontological usages of measurement sometimes occur. The implication of these arguments with regard to a view of empirical science is discussed. (shrink)

Kantian constructivists accord a constitutive, justificatory role to the issue of scope: they typically claim that first-order practical thought depends for its authority on being suitably acceptable within the right scope, or by all relevant others, and some Kantian constructivists, notably Onora O'Neill, hold that our views of the nature and criteria of practical reasoning also depend for their authority on being suitably acceptable within the right scope. The paper considers whether O'Neill-type Kantian constructivism can coherently accord this key role (...) to the issue of scope while adhering to the universalist, ‘cosmopolitan’ commitments at its core. The paper argues that this is not so. On the one hand, it shows that O'Neill's attempt to ‘fix’ the scope of practical reasoning supposes, rather than establishes, a view of ethical standing and the scope of practical reasoning. On the other hand, the paper argues that Kantian constructivism should endorse a non-constructivist, perfectionist view of the good to determine that scope. The paper thereby supports the perfectionist conjecture that Kantian constructivism, in order to defend its universalist commitments, should take refuge in non-constructivist, perfectionist considerations, and that Kantian constructivism should therefore construe perfectionism as a partial, though uneasy, ally. (shrink)